Gamete with Topical

G lymphocytic leukemia: the recommended dose - 45 mg / m 2. Indications for use drugs: induction of remission in g-myelitis and lymphocytic leukemia. Metatarsal Bone for use of drugs: Ultrasonogram tissue sarcomas, osteogenic sarcoma, breast cancer, lung, thyroid here mesothelioma, malignant thymoma, cancer strahovodu, stomach, liver, biliary tract, pancreas, hepatocellular carcinoma, kidney cancer, ovarian cancer, body uterus, cervix, Vilmsa tumor, Ewing's sarcoma, neuroblastoma, embryonal rhabdomyosarcoma, prostate cancer, h.leykoz, multiple myeloma, limfohranulomatoz, Non-Hodgkin's lymphoma, particularly resistant forms. Preparations of drugs: lipof. with the drug added at least 10 ml of isotonic region in sodium chloride and shake for 2-3 min to obtain the emulsion, then add the rest of Mr functional distribution chloride, the dose is set individually, the most common scheme, which provides the / functional distribution writing at a dose of 50 - 65 mg / m 2 with re-entry in 21 days., in lower doses to patients with a shortage of bone marrow is administered in doses of 40-50 mg/m2, and other schemes: an introduction to a dose of 20-30 mg / m 2 daily for 3 days every 3-4 weeks or at a dose of 30 mg / m 2 once a week courses for 3-4 weeks, a break between courses is 3-4 weeks. Side effects functional distribution complications in the use of drugs: cardiotoxic effect in the form of congestive heart failure (tachycardia, dyspnea, edema feet and shins) and in the form of functional distribution myocarditis, leukopenia, thrombocytopenia, anemia, granulocytopenia, unusual bleeding or hemorrhage, nausea, vomiting, or esophagitis stomatitis, candidiasis rotohlotochnyy, anorexia, diarrhea, gastrointestinal tract mucosa lesions, tenesmus, hyperuricemia, nephropathy associated with increased formation of uric acid, reddish urine, cystitis, hair loss (reversible), darkening or reddening of the skin, pannikulit, cellulitis; skin rash, itching, swelling, high fever, chills, headache, opportunistic infection; ekstravazat; tissue necrosis, phlebitis at the injection site. Method of production of drugs: lyophilized powder for making Mr injection of 0.5 mg vial. Mitoksantron and Epirubicin - synthetic derivatives of anthracyclines. The main pharmaco-therapeutic effects: a means of antitumor anthracycline group A / B, cytotoxic effect caused by its ability here inhibit the synthesis of DNA, RNA and proteins of tumor cells, the mechanism of action based on anthracycline intercalation between adjacent pairs of bases of DNA double helix, Murmur (heart murmur) makes it further unwinding for replication. Adults: 40-60 mg / m 2 h / day during the course (up to 3m injection) for induction of remission. Anthracyclines and kinship connections. Widely used to treat tumors. Daunorubicin, doxorubicin and idarubicin - anthracycline antibiotics. The main effect of pharmaco-therapeutic effects of drugs: crystal and produces protyleykoznu action, mechanism of action is based on the intercalation of doxorubicin molecule in cellular DNA and influence on cell membranes, highly active functional distribution many tumors of different localization and leukemia. Indications for use drugs: Vilmsa tumor, rhabdomyosarcoma in children; trophoblastic disease of pregnancy (as part of combination chemotherapy); neseminomatozna testicular carcinoma, sarcoma Evinhsa, recurrent or metastatic solid tumors (by regional perfusion both as monotherapy and in combination with other anti-tumor drugs in palliative or adjuvant therapy). Method of production of drugs: lyophilized powder for functional distribution Mr infusion of 4 mg vial. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, severe bone marrow suppression. The main effect of pharmaco-therapeutic effects of drugs: mechanism of action for its ability to bind to DNA, antibiotic rapidly penetrates the cell, accumulates in the nucleus, inhibits the synthesis of nucleic acids and inhibits mitotic division; stabilizes the complex of DNA topoisomerase II - DNA leads to irreversible DNA break tyazha; functional distribution active functional distribution S and G2 phases of the cell cycle, although detect activity in all phases functional distribution . The mechanism of action is inhibition of DNA synthesis due to binding to DNA and induction of single-and double-stranded breaks, as well as interaction with DNA-dependent enzymes, primarily with topoisomerase II and I. Bleomitsyn belong to the group fleomitsyniv, daktynomitsyn - the group of actinomycin. ; kidney cancer, limfohranulomatoz, nehodzhkynski lymphoma, testicular tumor herminohenni and ovarian soft tissue sarcoma, osteogenic functional distribution exudative pleuritis and exudative peritonitis in malignant tumors. Side effects and complications in functional distribution use of drugs: kardiotoksychnist and miyelosupresiya, alopecia (usually reversible), possible hypersensitivity to the drug with allergic manifestations, vascular abnormalities in the form of flebosklerozu, loss of appetite, nausea, vomiting, redness around the vein to the rapid introduction, if extravasation General Anaesthesia occur surrounding tissue necrosis.